The Biden administration unveiled a new plan to vaccinate eligible  Americans against monkeypox, prioritizing those who have been exposed to  the virus in states with the highest infection rates.

Hundreds of thousands of doses of the Jynneos vaccine from Bavarian  Nordic A/S will be made available under the administration’s new plan  through a tiered-allocation system, the US Department of Health and  Human Services said Tuesday.

Local officials will also be able to request Emergent BioSolutions  Inc.’s ACAM2000 vaccine, but it isn’t recommended for use for everyone,  such as immunocompromised people, due to “significant side effects.”

HHS will work with state and local health departments to get the shots  to those at highest risk, primarily in the LGBTQ community or people who  identify as men and have sex with men, a key part of the strategy to  combat the outbreak.

Cases have risen to more than 306 nationally, a number experts say is likely an undercount due to under testing.

“Our goal right now is to ensure that the limited supply of Jynneos  vaccine is deployed to those who can benefit from it most immediately,  as we continue to secure additional vaccine doses,” HHS Assistant  Secretary for Preparedness and Response Dawn O’Connell said in a  statement.

Unlike Covid-19, vaccination after monkeypox exposure can help  significantly slow the spread of the virus and protect those who are  most vulnerable, White House Covid Response Coordinator Ashish Jha said  on a call with media.

The new vaccination strategy expands the definition of who is considered  a direct contact, according to Jennifer McQuiston, the director of High  Consequence Pathogens and Pathology at the Centers for Disease Control  and Prevention.

The CDC previously focused its vaccination effort on high-risk contacts of monkeypox patients.

The new definition includes men who have sexual contact with men “who  have had multiple sex partners in a venue where there was known to be  monkeypox or in an area where monkeypox is spreading.”

The administration plans to allocate 296,000 Jynneos doses in the coming  weeks, including 56,000 that will be available immediately, according  to a release.

Over the coming months, a combined 1.6 million additional doses will be  made available, bolstering what is currently available in the country’s  Strategic National Stockpile.

Supplies of the Jynneos vaccine, which is administered in two shots spaced four weeks apart, are running short.

Last week, New York City’s Health Department opened appointments to  eligible New Yorkers, but its initial supply of 1,000 doses was  accounted for within days of the announcement.

Health officials said on June 24 that they were working to secure additional doses.