What to know about original antigenic sin and fall COVID boosts

Vaccine researchers say that additional study is required to understand how an early immune response, whether from vaccination or infection.

Experts agree that the first time a person is exposed to a virus is when their immune system learns how best to defend themselves.

Once a virus has undergone evolutionary changes, however, the immune system is less effective in combating it.

There are still unsolved issues, scientists say, despite the fact that we've been in the midst of an epidemic for over three years.

If public health officials knew the answers, they may use them to inform future vaccination efforts, such as vaccine formulation and dosing schedule.

According to specialists, the human immune system is at its most effective against a familiar intruder.

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