Week 1 NFL game picks: Rams knock off Bills; Seahawks surprise Russell Wilson-led Broncos

WHERE: SoFi Stadium (Inglewood, Calif.)WHEN: 8:20 p.m. ET | NBC, UniversoMONEYLINE: Bills: -135 | Rams: +115SPREAD: Rams +2.5 | O/U: 52

Los Angeles Rams vs Buffalo Bills


The Bills paid a premium to steal Von Miller from the Rams because Sean McDermott’s defense couldn’t get a finger on Patrick Mahomes in the playoffs.

While Buffalo’s pass rush should be better, the cornerback depth chart is a legitimate weakness until Tre’Davious White is back.

The defending champs should not be an underdog against anyone at home in the NFL Kickoff Game, even if they are facing the preseason Super Bowl favorites.

New Orleans Saints vs Atlanta Falcons
WHERE: Mercedes-Benz Stadium (Atlanta)WHEN: 1 p.m. ET | FOXMONEYLINE: Saints: -235 | Falcons: +192SPREAD: Saints -5.5 | O/U: 42.5

Perhaps I’m overrating the preseason, but the Saints’ starting group looked on it when given the chance in August.

Jameis Winston knows this scheme better than he did a year ago and his weapons are vastly improved.

This rivalry is full of surprises, and Falcons coach Arthur Smith could have schematic tricks up his sleeve, which makes this point spread imposing.

But New Orleans' edge up front on both sides should eventually wear down Atlanta.